PTEN gen polimorfizmleri, protein seviyeleri ve endometrium kanseri ilişkisi: Hastane bazlı vaka-kontrol çalışması

Association of PTEN Gene Polymorphisms, Protein Levels and Endometrial Cancer: A Hospital-Based Case-Control Study 
 Emine Yagci1, Hikmet Melike Ozturk1, Tufan Oge2, Cansu Ozbayer3, Hulyam Kurt1
 0000-0003-2179-1318, 0000-0002-1951-9713,0000-0002-1120-1874, 0000-0003-2433-9925
 1Eskisehir Osmangazi University, Faculty Medicine, Department Medical Biology, Eskisehir, Turkey.
 2 Eskisehir Gynecology, 3 Kutahya Health Sciences Faculty, Kutahya, Corresponding Author: Yagci, Telephone: +90 (222) 2392979/4598, e-mail adress: [email protected]
 Abstract
 cancer is a type that develops in the inner lining uterus, called endometrium. After breast, lung, colon cancer, endometrial most prevalent malignancy female genital system industrialized nations like North America Europe.
 Phosphatase Tensin homolog (PTEN), deleted on chromosome 10, tumor suppressor gene located 10q23.31, which encodes 403 amino acid protein with both lipid phosphatase activities. One common genetic abnormalities identified human malignancies are somatic mutations gene. The activity enzyme reduced or completely lost as result mutations. Considering this information, it thought polymorphisms may be associated pathogenesis disease. purpose our study to determine relationship between functional IVS4 (–/+) -9 C/G cancer.
 DNAs belonging 63 patients control individuals were genotyped by PCR-RFLP method for variants expression level was measured Elisa from serum samples. Our results evaluated appropriate statistical methods.
 As study, no statistically significant difference found risk genotype frequencies –9 (-/+) (p> 0.05). It detected lessened significantly comparison (p